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KMID : 1188320160100040649
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Gut and Liver
2016 Volume.10 No. 4 p.649 ~ p.652
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Differences in Clinical Manifestations according to the Positivity of Interferon-γ Assay in Patients with Intestinal Tuberculosis
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Jung Hye-Jin
Kim Young-Ho
Kim You-Sun
Jeong Seong-Yeon
Park Sung-Won
Seo Ji-Yeon
Jung Hye-mi
Im Jong-Pil
Kim Ji-Won
Hong Sung-Noh
Lee Kuk-Lae
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Abstract
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Intestinal tuberculosis (ITB) remains prevalent in Asia. An interferon-γ assay (QuantiFERON-TB gold test [QFT]) is considered to be an effective supplementary tool for diagnosing ITB. We retrospectively analyzed the clinical features of ITB patients based on the initial results of QFT. A total of 109 patients with ITB were enrolled, and 82 patients (75.2%) showed positive QFT results. In the QFT-positive group, the mean age (44.1±12.0 years) was significantly higher than that in the QFT-negative group (37.0±14.8, p=0.0096). Abdominal pain (p=0.006) and diarrhea (p=0.030) were more frequent in the QFT-negative group. Further, C-reactive protein (CRP) levels were significantly higher in the QFT-negative group (6.4±9.9 mg/dL) than in the QFT-positive group (1.3±2.3, p<0.001). Multivariate analysis confirmed that younger age (p=0.016), diarrhea (p=0.042), and high levels of CRP (p=0.029) were independent predictors of QFT-negative results in patients with ITB. These results suggest that prior exposure to TB, reflected by QFT positivity, may cause mild inflammation in patients with ITB.
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KEYWORD
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Intestinal tuberculosis, Interferon-gamma assay, C-reactive protein
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